- Title
- Prediction of on-treatment disability worsening in RRMS with the MAGNIMS score
- Creator
- Kunchok, Amy; Lechner-Scott, Jeannette; Izquierdo, Guillermo; Grammond, Pierre; Luis Sanchez-Menoyo, Jose; Van Wijmeersch, Bart; Boz, Cavit; Pucci, Eugenio; McCombe, Pamela; Grand'Maison, Francois; Spitaleri, Daniele; Vucic, Steve; Granella, Franco; Hupperts, Raymond; Jokubaitis, V; Sormani, MP; Butzkueven, H; Kalincik, T; Trojano, Maria; Alroughani, Raed; Sola, Patrizia; Ferraro, Diana; Lugaresi, Alessandra; Onofrj, Marco; Ozakbas, Serkan
- Relation
- Multiple Sclerosis Journal Vol. 27, Issue 5, p. 695-705
- Publisher Link
- http://dx.doi.org/10.1177/1352458520936823
- Publisher
- Sage
- Resource Type
- journal article
- Date
- 2020
- Description
- Background: The magnetic resonance imaging in multiple sclerosis (MAGNIMS) score combines relapses and magnetic resonance imaging (MRI) lesions to predict disability outcomes in relapsing–remitting multiple sclerosis (RRMS) treated with interferon-β. Objective: To validate the MAGNIMS score and extend to other disease-modifying therapies (DMTs). To examine the prognostic value of gadolinium contrast-enhancing (Gd+) lesions. Methods: This RRMS MSBase cohort study (n = 2293) used a Cox model to examine the prognostic value of relapses, MRI activity and the MAGNIMS score for disability worsening during treatment with interferon-β and three other DMTs. Results: Three new T2 lesions (hazard ratio (HR) = 1.60, p = 0.028) or two relapses (HR = 2.24, p = 0.002) on interferon-β (for 12 months) were predictive of disability worsening over 4 years. MAGNIMS score = 2 (1 relapse and ⩾3 T2 lesions or ⩾2 relapses) was associated with a greater risk of disability worsening on interferon-β (HR = 2.0, p = 0.001). In pooled cohort of four DMTs, similar associations were seen (MAGNIMS score = 2: HR = 1.72, p = 0.001). Secondary analyses demonstrated that the addition of Gd+ to the MAGNIMS did not materially improve its prediction of disability worsening. Conclusion: We have validated the MAGNIMS score in RRMS and extended its application to three other DMTs: 1 relapse and ⩾3 T2 lesions or ⩾2 relapses predicted worsening of disability. Contrast-enhancing lesions did not substantially improve the prognostic score.
- Subject
- multiple sclerosis; therapy; prediction; magnetic resonance imaging; outcomes; prognosis
- Identifier
- http://hdl.handle.net/1959.13/1462784
- Identifier
- uon:46553
- Identifier
- ISSN:1352-4585
- Language
- eng
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